Sezanne: Bio-Silver Nanoparticles-Zeolite Composite as Antibacterial Talcum powder
BOOTH NO : G8
Category : Health, Wellness & Wellbeing
Our lifestyle are impacted by body odor and skin disorders, which can be addressed by removing bad germs or bacteria on our skin. Sezanne, a green antibacterial compound developed based on scientific study, can be used to do this. The method of generating a zeolite loaded with biosynthesized silver nanoparticles (AgNP) utilizing plant extract has been filed for patent (PI2020006064), asserting the composite's uniqueness. For the production of AgNP on zeolite surfaces, the plant extract is used as a bioreducing agent. This composite shows significant antibacterial activity against common bacteria and safe for humans based on an in vitro human cell research. The product has reached TRL4 (Technology Readiness Level 4) and will require some investment. The market is vast because everyone is looking for an effective and environmentally friendly antimicrobial agent that will help us maintain a healthy and hygienic lifestyle, which has also been affected by the COVID19 pandemic.
Malaysia, a tropical country with high humidity and temperature, is an ideal environment for microorganism growth. When nasty germs or bacteria affected the skin, the odor and skin condition might get much worse. These issues cause secondary issues that are unpleasant and can develop to serious skin problems, which can lead to hospitalization. The expense of hospitalization is extremely expensive, putting a strain on the low-income society. As a result, preventing bacterial growth on our bodies is critical in resolving this issue. It can be done by applying Sezanne to certain areas of our bodies, with silver nanoparticles (AgNP) embedded on zeolites performing the antibacterial effect. Immobilizing AgNP on zeolite could also reduce the amount of AgNP used, lowering the amount of silver released into the environment. The environmentally friendly method of producing AgNP using plant extract could replace the hazardous chemical procedure.
Because of COVID19, everyone is looking for an effective antimicrobial product, the global market for silver nanoparticles is very large.
However, the widespread use of silver nanoparticles will result in secondary and, eventually, tertiary issues such as bacterial resistance to antimicrobial agents and environmental pollution.
Bacterial resistance to silver nanoparticles is expected to occur in the future if this material is widely used as an antimicrobial agent globally and in our daily lives.
Furthermore, the high demand for silver nanoparticles synthesized from physical and chemical synthesis methods involve the use of hazardous chemicals and high energy output.
As a result, in order to carry out a more sustainable production or alternative, it is necessary to adhere to the Sustainable Development Goals (SDG).
Silver nanoparticles can be used more efficiently if they are immobilised on a suitable carrier system, such as zeolite.
Zeolite was chosen because it has a high surface area and porosity, as well as being stable and inert. Because it is a mineral, it is also safe for humans.
In the biological synthesis approach, plant extract is used as a bioreducing agent to prepare immobilised silver nanoparticles on zeolite.
This green approach can be used as an alternative to physical and chemical approaches, and the plant extract is much safer than using hazardous chemicals.
Sezanne is a talc that contains immobilised silver nanoparticles on zeolite with plant extract and talc mineral.
Sezanne contains Bio-AgNP-Zeolite, a beneficial combination of silver nanoparticles, plant bioactive compounds, and zeolite.
In terms of efficacy, the product kills various types of pathogenic bacteria and is unlikely to cause bacterial resistance.
According to in vitro cell culture assays, the product can increase the viability and proliferation of human skin cells and has been proven to be safe for human skin.
In terms of manufacturing, the production does not require a lot of energy, a complicated reactor, a lot of heat, a lot of solvent, and so on, so the production cost is low.
The amount of silver nanoparticles is low because they are immobilised on zeolite, but they are still effective.
Any medicated talc that has a similar function, such as antibacterial activity, is a competitor for Sezanne.
The main competitor is Agnesia talcum powder. This product contains copper oxide, an inorganic antibacterial agent with lower activity than silver.
Johnson&Johnson's talcum powder is another competitor. However, this commercial product has a controversy in that it contains asbestos, which is a known carcinogen.
There is no antibacterial talcum powder on the market derived from silver nanoparticles, unlike Sezanne, which contains silver nanoparticles immobilised zeolite.
The Sezanne will be marketed by a number of industrial partners.
ClayNiQ Enterprise, which specializes in mineral materials for health and medical applications, will license the patent to UTM for the production of Bio-AgNP-Zeolite.
Biopro Consortium Sdn Bhd, an OEM with a GMP facility, will manufacture the Sezanne talcum powder.
Following that, Youbaby Millions Sdn Bhd and ClayRa Beauty and Health Enterprise will distribute the Sezanne product.
Many industrial partners will be involved in this commercialization strategy to ensure a high market segmentation for the product.
NIK AHMAD NIZAM BIN NIK MALEK
FAKULTI SAINS
JUAN BIN MATMIN
FAKULTI SAINS
KHAIRUNADWA BINTI JEMON
FAKULTI SAINS
MARIANI BINTI ABDUL HAMID
FAKULTI KEJURUTERAAN KIMIA DAN KEJURUTERAAN TENAGA
MUHAMMAD HARIZ ASRAF BIN HASSAN
SCIENCE
NIK AHMAD NIZAM BIN NIK MALEK
FAKULTI SAINS
NOR SURIANI BINTI SANI
JABATAN TIMBALAN NAIB CANSELOR (PENYELIDIKAN DAN INOVASI)
SHAHRULNIZAHANA BINTI MOHAMMAD DIN
SCIENCE
TS DR. MOHD ALIFF AFIRA SANI
UNIVERSITI KUALA LUMPUR